GABA
"Studies Show A 550% Increase In Growth Hormone Levels With Just 5
Grams Of GABA!"
Product Information
GABA,
Gamma Aminobutyric Acid, is an amino acid classified as a neurotransmitter
(A neurotransmitter is a substance that transmits nerve impulses across a
synapse. A synapse is a region where nerve impulses are transmitted across
axon terminals.) Studies have shown GABA to play a key role in the
secretion of Growth Hormone. The principle anabolic actions of Growth
Hormone include the stimulation of amino acid transport, stimulation of
protein synthesis and the proliferation of cell growth.
GABA’s high concentration in the hypothalamus suggests this amino acid
plays a significant role in hypothalamic-pituitary function. The
hypothalamus is a region of the posterior section of the brain and is the
regulating center for visceral (instinctive) functions such as sleep
cycles, body temperature, and the activity of the pituitary gland.
The pituitary gland is the master endocrine gland effecting all
hormonal functions of the body. One primary hormone of concern to the
athlete is growth hormone (GH) and its various hormonal constituents.
The amino acid GABA has been shown in numerous studies to promote
significant increases in plasma growth hormone levels.
There have been literally hundreds of clinical studies on GABA and
numerous studies on GABA’s ability to elevate growth hormone levels. As
with most nutritional studies, GABA research has come directly from the
medical community. One noted study from the First Medical Clinic at the
University of Milan in Milan, Italy titled, "Effect of acute and repeated
administration of gamma aminobutyric acid (GABA) on growth hormone and
prolactin secretion in man", shows just how effective GABA is.
Quoted results from this study showed "In all of the 19 subjects
studied, compared with 18 controls, plasma growth hormone levels were
significantly increased (above 5 ng/ml) by acute oral administration of 5
g of GABA."
This study showed over a 5 1/2 fold increase in plasma growth hormone
levels 90 minutes after GABA administration. That is a significant
increase unmatched by any other nutritional means.
Most cited studies on amino acids and growth hormone elevation utilize
intravenous delivery means. This is unrealistic and doesn’t reflect real
world results. Studies on GABA have been performed with both oral and
intravenous administration with the oral route showing remarkable
effectiveness.
GABA’s growth hormone elevating effects rival that of potent
pharmaceutical compounds.
References
1. Involvement of growth hormone-releasing factor
in growth hormone secretion induced by gamma-aminobutyric acid in
conscious rats. Murakami Y, 1985 Endocrinology 117(2), 787-789 (1985)
2. Evidence for a GABAergic control of the exercise-induced rise in GH
in man. Steardo L, Iovino M, Monteleone P, Agrusta M, Orio F Eur J Clin
Pharmacol 28 (5): 607-609 (1985)
3. Growth hormone secretion of the neonatal rat pituitaries is
stimulated by gamma-aminobutyric acid in vitro. Acs Z, Makara GB, Stark E
Life Sci 34 (16): 1505-1511 (Apr 1984)
4. Gamma aminobutyric acid (GABA), a modulator of anterior pituitary
hormone secretion by hypothalamic and pituitary action. McCann SM, Vijayan
E, Negro-Vilar A, Mizunuma H, Mangat H Psychoneuroendocrinology 9 (2):
97-106 (1984)
5. Effect of gamma-aminobutyric acid on growth hormone and prolactin
secretion in man: influence of pimozide and domperidone. Cavagnini F,
Benetti G, Invitti C, Ramella G, Pinto M, Lazza M, Dubini A, Marelli A,
Muller EE J Clin Endocrinol Metab 51 (4): 789-792 (Oct 1980)
6. Effects of some gamma-aminobutyric acid (GABA)-ergic drugs on the
dopaminergic control of human growth hormone secretion. Koulu M,
Lammintausta R, Dahlstrom S J Clin Endocrinol Metab 51 (1): 124-129 (Jul
1980)
7. Effect of acute and repeated administration of gamma aminobutyric
acid (GABA) on growth hormone and prolactin secretion in man. Cavagnini F,
Invitti C, Pinto M, Maraschini C, Di Landro A, Dubini A, Marelli A Acta
Endocrinol (Copenh) 93 (2): 149-154 (Feb 1980)
"A single oral dose of 5 g gamma aminobutyric acid (GABA) was given to
19 subjects and serial venous blood samples were obtained before and 3 h
after drug administration. A placebo was administered to 18 subjects who
served as controls. GABA caused a significant elevation of plasma growth
hormone levels (P less than 0.001), but did not consistently alter plasma
prolactin concentration since only 5 out of 15 subjects showed an increase
of the hormone. Eight additional subjects were submitted to an insulin
tolerance test before and after per os administration of 18 g GABA daily
for 4 days. Protracted GABA treatment significantly blunted the response
of growth hormone and enhanced that of prolactin to insulin hypoglycaemia
(P less than 0.01). These results indicate that pharmacological doses of
GABA affect growth hormone and prolactin secretion in man. The precise
nature of GABA's effects as well as its mechanism of action remains to be
clarified."
8. Growth hormone release by gamma-aminobutyric acid (GABA) and
gamma-amino-beta-hydroxybutyric acid (GABOB) in the rat. Abe H, Kato Y,
Chihara K, Ohgo S, Iwasaki YEndocrinol Jpn 24 (2): 229-231 (Apr 1977)
9. Regulation of growth hormone secretion Kato Y, Chihara K, Daigo S,
Iwasaki Y, Abe H Horumon To Rinsho 25 (2): 131-141 (Feb 1977)
10. Pharmacological evidence for a dual GABAergic regulation of growth
hormone release in humans. Steardo L, Iovino M, Monteleone P, Agrusta M,
Orio F Life Sci 39 (11): 979-985 (Sep 1986)
11. Involvement of alpha-adrenergic and GABAergic mechanisms in growth
hormone secretion induced by central somatostatin in rats. Murakami Y,
Kato Y, Koshiyama H, Inoue T, Ishikawa Y, Imura H Brain Res 407 (2):
405-408 (Mar 1987)
12. Evidence for a sex difference in the basal growth hormone response
to GABAergic stimulation in humans. Monteleone P, Maj M, Iovino M, Steardo
L Acta Endocrinol (Copenh) 119 (3): 353-357 (Nov 1988)
13. Role of hypothalamic factors (growth-hormone-releasing hormone and
gamma-aminobutyric acid) in the regulation of growth hormone secretion in
the neonatal and adult rat. Acs Z, Lonart G, Makara GB Neuroendocrinology
52 (2): 156-160 (Aug 1990)
14. Possible mediation of GABA induced growth hormone secretion by
increased calcium-flux in neonatal pituitaries. Acs Z, Zsom L, Makara GB
Life Sci 50 (4): 273-279 (1992)
15. Potent agonists of growth hormone-releasing hormone. II. Zarandi M,
Serfozo P, Zsigo J, Deutch AH, Janaky T, Olsen DB, Bajusz S, Schally AV
Pept Res 5 (4): 190-193 (Jul 1992)
16. New Gaba-containing analogues of human growth hormone-releasing
hormone (1-30)-amide: I. Synthesis and in vitro biological activity. Mezo
I, Kovacs M, Szoke B, Szabo EZ, Horvath J, Makara GB, Rappay G, Tamas J,
Teplan I J Endocrinol Invest 16 (10): 793-798 (Nov 1993)
17. Neuroendocrine regulation of growth hormone secretion in sheep.
VII. Effects of GABA. Spencer GS, Berry CJ, Bass JJ Regul Pept 52 (3):
181-186 (Aug 1994)
18. Growth hormone secretion and activation of cyclic AMP by growth
hormone releasing hormone and gamma-aminobutyric acid in the neonatal rat
pituitary. Mergl Z, Acs Z, Makara GB Life Sci 56 (8): 579-585 (1995)
Label Information
Servings per container: 33
Serving
size: 3 Scoops
Amount per serving:
| Gamma Aminobutyric Acid |
3 g |
Recommended use
For adults only. As a dietary supplement,
take three to five grams mixed with 8 ounces of water or juice
approximately 30 minutes before sleep.
Warning(s)
GABA is a naturally occuring amino acid classified
as a neutrotransmitter. Some individuals may experience a minor tingling
of the skin and/or slight shortness of breath shortly after taking GABA.
This is characteristic of this amino acid and quickly subsides.
AST Sport Science selectively imports GABA under rigid quality control
conditions. Each batch is HPLC Certified and Laboratory Tested for purity
and potency.
Made in USA
Copyright 2002 CLF Distribution Ltd.
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